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Toll-Like Receptor 10 (TLR10) antibody

Details for Product No. ABIN493512, Supplier: Log in to see
Antigen
  • TLR10
  • CD290
Alternatives
anti-Human Toll-Like Receptor 10 antibody for Western Blotting
Reactivity
Human
65
7
5
2
2
2
Host
Rabbit
54
13
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
54
14
11
10
6
6
5
3
2
2
1
Supplier
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Immunogen Synthetic peptidess corresponding to unique epitope on TLR10.
Isotype IgG
Specificity This antibody detects a single band of approximately 97.3 kDa in Western blot positive control samples for TLR10 and several other tissues.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography using immobilized antigen
Alternative Name CD290 / TLR10 (TLR10 Antibody Abstract)
Background Toll-like receptor 10 (TLR10) is a member of TLR family, it is located on human chromosome 4p14. TLR family recognizes pathogens and also plays an important role in the activation of innate immunity to fight infectious diseases that pose a major threat to the health and survival of human beings (1). In humans, TLR family comprises of 10 functioning receptors (TLR1-TLR10), each of which can be classified based on their subcellular distribution and also their known agonists (2). TLR 10 is expressed on the cell surface, however, it is the only remaining orphan receptor in the TLR family. TLR10's ligand(s) have yet to be identified (3). Similar to other members of TLR family, it associates with MyD88, the common Toll IL-1 receptor domain adapter. TLR10 is known to form homodimers and also heterodimers with TLR1 and TLR2 (4). Expression of TLR10 is highly restricted. It is expressed as a highly N-glycosylated protein detected in B cell lines, B cells from peripheral blood, and in plasmocytoid dendritic cells from tonsils (5). TLR10 was also found to be expressed in lungs. It has been suggested that TLR10 may play a role in the recognition of airborne pathogens or airborne allergies (6). Genetic variation in TLR10 was found to be associated with asthma. TLR10 may also be involved in the genetics of preterm birth. It was discovered that haplotypes of TLR10 were associated with preterm birth (7). TLR10 is approximately a 97.3 kDa protein (811 amino acids).Synonyms: Toll-like receptor 10, UNQ315/PRO358
Molecular Weight 97.3 kDa
Gene ID 81793
NCBI Accession NP_001017388
UniProt Q9BXR5
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling
Application Notes ELISA: < 1/10,000. Western Blot: > 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.64-0.72 mg/mL
Buffer Stabilization buffer
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at-20 °C.
Background publications Barreiro, Ben-Ali, Quach et al.: "Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense." in: PLoS genetics, Vol. 5, Issue 7, pp. e1000562, 2009 (PubMed).

Heinzmann, Mailaparambil, Mingirulli et al.: "Association of interleukin-13/-4 and toll-like receptor 10 with preterm births." in: Neonatology, Vol. 96, Issue 3, pp. 175-81, 2009 (PubMed).

Nyman, Stenmark, Flodin et al.: "The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 11861-5, 2008 (PubMed).

Nikoobakht, Tajik, Karami et al.: "Premature ejaculation and serum leptin level: a diagnostic case-control study." in: The journal of sexual medicine, Vol. 5, Issue 12, pp. 2942-6, 2008 (PubMed).

Kawai, Akira: "Innate immune recognition of viral infection." in: Nature immunology, Vol. 7, Issue 2, pp. 131-7, 2006 (PubMed).

Hasan, Chaffois, Gaillard et al.: "Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 5, pp. 2942-50, 2005 (PubMed).

Lazarus, Raby, Lange et al.: "TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples." in: American journal of respiratory and critical care medicine, Vol. 170, Issue 6, pp. 594-600, 2004 (PubMed).

Medzhitov: "Toll-like receptors and innate immunity." in: Nature reviews. Immunology, Vol. 1, Issue 2, pp. 135-45, 2002 (PubMed).