Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

GOPC antibody (Middle Region)

GOPC Reactivity: Human, Mouse WB, IF, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN497985
  • Target See all GOPC Antibodies
    GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))
    Binding Specificity
    • 15
    • 11
    • 7
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 82
    • 33
    • 10
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 81
    • 1
    Rabbit
    Clonality
    • 73
    • 9
    Polyclonal
    Conjugate
    • 29
    • 8
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GOPC antibody is un-conjugated
    Application
    • 44
    • 30
    • 30
    • 14
    • 14
    • 11
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    Recognizes PIST (Intermediate Domain).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human and Mouse.
    Purification
    Immunoaffinity Chromatography
    Immunogen
    17 amino acid peptide from near the center of Human PIST (Genbank accession No. AAG00572).
    Isotype
    IgG
    Top Product
    Discover our top product GOPC Primary Antibody
  • Application Notes
    ELISA. Western Blot: PIST antibody can be used for the detection ob PIST at 1-2 μg/mL. Positive Control: PC-3 Cell Lysate. Immunohistochemistry on paraffin sections. Positive Control: Rat Colon Cell Lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))
    Alternative Name
    GOPC / PIST (GOPC Products)
    Synonyms
    DKFZp459H2130 antibody, 2210402P09Rik antibody, AI844555 antibody, CAL antibody, FIG antibody, GOPC1 antibody, PIST antibody, fe38f01 antibody, wu:fe38f01 antibody, zgc:56254 antibody, zgc:65853 antibody, dJ94G16.2 antibody, cal antibody, gopc1 antibody, pist antibody, golgi associated PDZ and coiled-coil motif containing antibody, golgi-associated PDZ and coiled-coil motif containing antibody, golgi-associated PDZ and coiled-coil motif containing S homeolog antibody, GOPC antibody, Gopc antibody, gopc antibody, gopc.S antibody
    Background
    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). PIST, a PDZ-containing protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (4-6). Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1. (6)Synonyms: CAL, CFTR-associated ligand, FIG, Fused in glioblastoma, Golgi-associated PDZ and coiled-coil motif-containing protein, PDZ protein interacting specifically with TC10
    Gene ID
    57120
    NCBI Accession
    NP_001017408
    UniProt
    Q9HD26
    Pathways
    Maintenance of Protein Location, Asymmetric Protein Localization
You are here:
Support