Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 7 (SLC17A7) antibody

Antigen: Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 7 (SLC17A7)

Synonyms: BNPI, Vglut1, vglut1, MGC163045, VGLUT1, AI851913, 2900052E22Rik, vglut2, slc17a6, MGC83509, SLC17A7, slc17a7, MGC146483

Clonality: Polyclonal

Host: Goat

Reactivity: Cow (Bovine)

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN498056

Additional Information

Characteristics: Synonyms: Vesicular glutamate transporter 1, BNPI, Solute carrier family 17 member 7, Brain-specificNa(+)-dependent inorganic phosphate cotransporter

Alternative name: SLC17A7 / VGLUT1

Gene ID: 57030

Swiss-Prot: Q9P2U7

Immunogen: Peptide with sequence C-HDQLAGSDDSEMED, from the internal region of the proteinsequence according to NP_064705. 1. Genename: SLC17A7

Cross-Reactivity: Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)

Description: VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into nativesynaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked byglutamate. Vesicular glutamate transport has a substantially lower apparent affinity thanthe plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1is saturated with a K(m) of approximately 2 mM, in the same range as transport by synapticvesicles. Finally, plasma membrane glutamate transporters recognize both aspartate andglutamate as substrates, whereas VGLUT1 does not recognize aspartate.

Specificity: Recognizes VGLUT1Species Reactivity: Tested: HumanExpected from sequence similarity: Mouse, Rat, Canine (Dog), Bovine

Application Details

Application Notes: Peptide ELISA: Detection Limit: 1/32000. Immunohistochemistry on Paraffin Embedded Sections: 3-5 µg/ml. In paraffin embedded Human Cortex shows vesicular staining amongst the many axonsand dendrites. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.5 mg/ml

Purification: Aff - Purified

Buffer: Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and0.5% BSA as stabilizer.

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only