KAT1 antibody, HAC07 antibody, HAC7 antibody, HAG02 antibody, MIK19.19 antibody, MIK19_19 antibody, histone acetyltransferase of the GNAT family 2 antibody, hac106 antibody, hat1 antibody, zgc:92639 antibody, histone acetyltransferase 1 antibody, histone acetyltransferase of the GNAT family 2 antibody, histone acetyltransferase catalytic subunit antibody, histone acetyltransferase Hat1 antibody, histone acetyltransferase 1 L homeolog antibody, HAT1 antibody, Hat1 antibody, HAG2 antibody, hat1 antibody, hat1.L antibody
Background
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBPassociated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases.Synonyms: Histone acetyltransferase type B catalytic subunit