HSD17B10 antibody

Catalog No. ABIN498183

Product Details anti-HSD17B10 Antibody

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of HADH2 protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for HSD17B10

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Alternative Name: HSD17B10 / ERAB (HSD17B10 Products)

Synonyms: hadh2 antibody, im:6899159 antibody, wu:fj61f03 antibody, zgc:101605 antibody, abad antibody, camr antibody, erab antibody, hcd2 antibody, hsd10 antibody, mhbd antibody, mrpp2 antibody, mrx17 antibody, mrx31 antibody, mrxs10 antibody, schad antibody, sdr5c1 antibody, HADH2 antibody, HSD17B10 antibody, 17b-HSD10 antibody, ABAD antibody, CAMR antibody, DUPXp11.22 antibody, ERAB antibody, HCD2 antibody, MHBD antibody, MRPP2 antibody, MRX17 antibody, MRX31 antibody, MRXS10 antibody, SCHAD antibody, SDR5C1 antibody, 17bHSD10 antibody, Ads9 antibody, Hadh2 antibody, hydroxysteroid (17-beta) dehydrogenase 10 antibody, hydroxysteroid 17-beta dehydrogenase 10 antibody, hydroxysteroid (17-beta) dehydrogenase 10 L homeolog antibody, HSD17B10 antibody, hsd17b10 antibody, hsd17b10.L antibody, Hsd17b10 antibody

Background: β-Amyloid is a neurotoxic peptide that is associated with the pathogenesis of Alzheimer's disease. β-Amyloid aggregates induce cell death of neurons through the disruption of cell membranes and the generation of reactive oxygen intermediates.These neurotoxic effects are also attributed to the interaction of β-Amyloid with intracellular proteins, specifically ERAB, the endoplasmic reticulum-associated β-Amyloid-binding protein. ERAB is characterized as a NAD+-dependent dehydrogenase that is constitutively expressed in tissues and overexpressed in neurons affected in Alzheimer's disease. Cells overexpressing ERAB in vitro have been shown to be more sensitive to β-Amyloid-induced stress, and blocking the activity of ERAB has been shown to inhibit this cell death, indicating that β-Amyloid induced cell death is mediated by ERAB.Synonyms: 17-beta-HSD10, 17-beta-hydroxysteroid dehydrogenase 10, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase type II, 3-hydroxyacyl-CoA dehydrogenase type-2, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, HADH2, MRPP2, Mitochondrial Marker, Mitochondrial ribonuclease P protein 2, SCHAD, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH, XH98G2

Molecular Weight: approx. 27 kDa

Gene ID: 3028

NCBI Accession: NP_001032900

UniProt: Q99714