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PFKFB1 antibody

PFKFB1 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN498309
  • Target See all PFKFB1 Antibodies
    PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))
    Reactivity
    • 41
    • 31
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 55
    • 1
    Rabbit
    Clonality
    • 56
    Polyclonal
    Conjugate
    • 20
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This PFKFB1 antibody is un-conjugated
    Application
    • 48
    • 26
    • 21
    • 13
    • 13
    • 10
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of PFK-2 liv protein. (region surrounding Glu442)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity-Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product PFKFB1 Primary Antibody
  • Application Notes
    Western Blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2 containing 15 mM Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))
    Alternative Name
    PFKFB1 (PFKFB1 Products)
    Synonyms
    zgc:55328 antibody, wu:fi11h10 antibody, PFKFB1 antibody, F6PK antibody, HL2K antibody, PFRX antibody, Pfkfb01 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 S homeolog antibody, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 antibody, pfkfb1 antibody, PFKFB1 antibody, pfkfb1.S antibody, LOC100475853 antibody, Pfkfb1 antibody
    Background
    Phosphofructokinases (PFK) are regulatory glycolytic enzymes that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2), and ADP. Human PFK-1 is tetrameric and isoenzymes include, PFK-1 muscle (PFKM, PFK-A), PFK-1 liver (PFKL, PFK-B), and PFK-1 platelet (PFKP, PFK-C, PFKF). PFK-1 is inhibited by ATP and citrate (from the tricarboxylic acid cycle). PFK-1 undergoes activation in the presence of elevated AMP. The most potent activator is fructose-2,6-bisphosphate, which is produced by PFK-2 from the same substrate, fructose 6-phosphate. PFK-2 is bifunctional and a key regulator for PFK-1. PFK-2 catalyzes the synthesis of fructose-2,6-bisphosphate, and contains fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. PFK-2 is dimeric and isoenzymes include PFK-2 liver (PFKFB1, PFRX), PFK-2 cardiac (PFKFB2), PFK-2 placental (PFKFB3, inducible PFK-2) and PFK-2 testis (PFKFB4).Synonyms: 6-biphosphatase 1, 6-phosphofructo-2-kinase/fructose-2, F6PK, PFK-2 liver, PFK/FBPase 1, PFRX
    Molecular Weight
    approx. 52 kDa
    Gene ID
    5207
    NCBI Accession
    NP_002616
    UniProt
    P16118
    Pathways
    Regulation of Carbohydrate Metabolic Process
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