PER3 antibody (Period Homolog 3 (Drosophila))

Details for Product anti-PER3 Antibody No. ABIN498324, Supplier: Log in to see
Antigen
  • period3
  • rper3
  • GIG13
  • 2810049O06Rik
  • mPer3
  • period circadian clock 3
  • Per3
  • PER3
Reactivity
Human
37
10
9
3
3
2
2
1
1
1
Host
Rabbit
31
8
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
37
19
12
4
3
3
2
1
1
Options
Supplier
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Specificity This antibody detects endogenous levels of Per3 protein. (region surrounding Pro2)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography using epitope-specific immunogen.
Alternative Name PER3 (PER3 Antibody Abstract)
Background Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. A number of transcription factors appearing to be molecular components of the SCN clock have been identified. Mutations within the Clock gene increase the length of the endogenous period and cause a loss of rhythmicity of circadian oscillations. Three mammalian period proteins, designated Per1, Per2 and Per3, exhibit circadian rhythyms in the SCN.During subjective night, Per1 and Per2 RNA levels increase in response to light pulses while Per3 RNA levels show no change in response to light pulses. Tim, for timeless, interacts with Per1 as well as Per2, and Tim and Per1 negatively regulate Clock-BMAL1-induced transcription.Synonyms: Cell growth-inhibiting gene 13 protein, Circadian clock protein PERIOD 3, GIG13, Period circadian protein homolog 3, hPER3
Molecular Weight approx. 43 kDa
Gene ID 8863
NCBI Accession NP_058515
UniProt P56645
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Western blot 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Period Homolog 3 (Drosophila) (PER3) antibody (ABIN498324) Western blot analysis of Per3 antibody in extracts from Jurkat cells treated w...
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