FOXE3 antibody

Catalog No. ABIN498337

Product Details anti-FOXE3 Antibody

Target: FOXE3 (Forkhead Box E3 (FOXE3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXE3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of FOXE3 protein. (region surrounding Arg97)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % Sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FOXE3

Target: FOXE3 (Forkhead Box E3 (FOXE3))

Alternative Name: FOXE3 / FKHL12 (FOXE3 Products)

Synonyms: FOXE3 antibody, FKHL12 antibody, FREAC8 antibody, dyl antibody, rct antibody, FREAC-8 antibody, HFH7 antibody, HNF3 antibody, foxe4 antibody, lens1 antibody, lens1-A antibody, forkhead box E3 antibody, forkhead box E3 L homeolog antibody, foxe3 antibody, FOXE3 antibody, LOC100301611 antibody, Foxe3 antibody, foxe3.L antibody

Background: The human forkhead-box (FOX) gene family consists of at least 43 members, including FOXE3, a 288-amino acid protein. FOXE3 is a winged-helix transcription factor that plays a crucial role during the initial stages of lens development and closure of the lens vesicle. FOXE3 may also act as a factor that promotes survival and proliferation while preventing differentiation in the lens epithelium. As the posterior cells of the lens fiber begin to differentiate, expression of FOXE3 is limited to the undifferentiated cells coating the anterior surface of the lens. Congenital primary aphakia (CPA) is a rare developmental disorder caused by a null mutation in the FOXE3 gene that is identified by the absence of a lens. The development of CPA is normally stimulated during the fourth or fifth week of human embryogenesis.Synonyms: FREAC8, Forkhead box protein E3, Forkhead-related protein FKHL12, Forkhead-related transcription factor 8

Molecular Weight: approx. 33 kDa

Gene ID: 2301

NCBI Accession: NP_036318

UniProt: Q13461