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ARR3 antibody

ARR3 Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN498372
  • Target See all ARR3 Antibodies
    ARR3 (Arrestin 3, Retinal (X-Arrestin) (ARR3))
    Reactivity
    • 19
    • 11
    • 2
    • 1
    Human
    Host
    • 15
    • 3
    • 1
    Rabbit
    Clonality
    • 18
    • 1
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ARR3 antibody is un-conjugated
    Application
    • 11
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of Arrestin-C protein. (region surrounding Glu374)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product ARR3 Primary Antibody
  • Application Notes
    Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry: 1/50-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ARR3 (Arrestin 3, Retinal (X-Arrestin) (ARR3))
    Alternative Name
    Arrestin C / ARR3 (ARR3 Products)
    Synonyms
    ARRX antibody, arr3 antibody, si:bz46j2.6 antibody, zgc:73331 antibody, Arr4 antibody, Car antibody, Carfl antibody, Carr antibody, arr3l antibody, c-arrestin antibody, zgc:92697 antibody, arrestin 3 antibody, arrestin 3, retinal (X-arrestin) L homeolog antibody, arrestin 3, retinal (X-arrestin) antibody, arrestin 3b, retinal (X-arrestin) antibody, arrestin 3, retinal antibody, arrestin 3a, retinal (X-arrestin) antibody, ARR3 antibody, arr3.L antibody, arr3 antibody, arr3b antibody, Arr3 antibody, arr3a antibody
    Background
    Members of Arrestin/beta-Arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters or sensory signals. Arrestin-C, also known as retinal cone Arrestin-3, X-Arrestin or cArr, is a member of the Arrestin family of proteins. It is predominantly found in the retina and pineal gland and localizes to the inner and outer segments of red-, green- and blue-cone photoreceptors and the inner plexiform regions. Two Arrestin-C isoforms exist due to alternative splicing. Isoform 1 is the mature full length protein and isoform 2 is truncated, ending with an arginine for amino acid residue 359. Arrestin-C expression is stimulated by retinoic acid. It may play a role in retina-specific signal transduction and bind to photoactivated-phosphorylated red/green opsins. In addition, Arrestin-C forms homodimers and oligomers with beta-Arrestins and may regulate beta-Arrestin mediated signaling.Synonyms: ARRX, C-ARR, C-Arrestin, CAR, Cone arrestin, Retinal cone arrestin-3, X-arrestin
    Molecular Weight
    approx. 40 kDa
    Gene ID
    407
    NCBI Accession
    NP_004303
    UniProt
    P36575
    Pathways
    Phototransduction, Thromboxane A2 Receptor Signaling
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