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DIDO1 antibody

DIDO1 Reactivity: Human, Mouse WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN498449
  • Target See all DIDO1 Antibodies
    DIDO1 (Death Inducer-Obliterator 1 (DIDO1))
    Reactivity
    • 29
    • 10
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 23
    • 6
    Rabbit
    Clonality
    • 26
    • 3
    Polyclonal
    Conjugate
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DIDO1 antibody is un-conjugated
    Application
    • 20
    • 10
    • 9
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of DIDO1 / Dio-1 protein. (region surrounding Ser186)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse.
    Purification
    Affinity Chromatography using epitope-specific immunogen
    Top Product
    Discover our top product DIDO1 Primary Antibody
  • Application Notes
    Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    DIDO1 (Death Inducer-Obliterator 1 (DIDO1))
    Alternative Name
    DIDO1 (DIDO1 Products)
    Synonyms
    5DI antibody, TXDI1 antibody, BYE1 antibody, C20orf158 antibody, DATF-1 antibody, DATF1 antibody, DIDO2 antibody, DIDO3 antibody, DIO-1 antibody, DIO1 antibody, dJ885L7.8 antibody, 6720461J16Rik antibody, C530043I07 antibody, D130048F08Rik antibody, Datf1 antibody, Dido2 antibody, Dido3 antibody, mKIAA0333 antibody, DIDO1 antibody, datf1l antibody, fi35b04 antibody, wu:fi35b04 antibody, zgc:158157 antibody, DKFZp469J1523 antibody, bye1 antibody, dio1 antibody, datf1 antibody, dido2 antibody, dido3 antibody, dio-1 antibody, iodothyronine deiodinase 1 antibody, death inducer-obliterator 1 antibody, death inducer-obliterator 1 L homeolog antibody, DIO1 antibody, DIDO1 antibody, Dido1 antibody, dido1.L antibody, dido1 antibody
    Background
    DIDO1 / Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFκB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death.Synonyms: C20orf158, DATF1, Death-inducer obliterator 1, KIAA0333
    Molecular Weight
    approx. 244 kDa
    Gene ID
    11083
    NCBI Accession
    NP_071388
    UniProt
    Q9BTC0
    Pathways
    Hormone Activity
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