NPY antibody
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- Target See all NPY Antibodies
- NPY (Neuropeptide Y (NPY))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NPY antibody is un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- This antibody detects endogenous levels of NPY protein. (region surrounding Pro94)
- Cross-Reactivity (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Affinity chromatography
- Purity
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product NPY Primary Antibody
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- Application Notes
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Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- NPY (Neuropeptide Y (NPY))
- Alternative Name
- Neuropeptide Y / NPY (NPY Products)
- Synonyms
- 0710005A05Rik antibody, PYY4 antibody, NPY02 antibody, RATNPY antibody, RATNPY02 antibody, si:dkey-22m8.5 antibody, npy antibody, npyb antibody, preproNPY antibody, pyy4 antibody, xnpy antibody, npya antibody, MGC86288 antibody, prepronpy antibody, NPY antibody, NPY1 antibody, neuropeptide Y antibody, neuropeptide Y S homeolog antibody, neuropeptide Y L homeolog antibody, Npy antibody, NPY antibody, npy antibody, npy.S antibody, npy.L antibody, LOC100533423 antibody
- Background
- A gene located on chromosome 7p15.1 encodes a 36-amino acid protein designated NPY (Neuropeptide Y). NPY consists of a polyproline stretch followed by an amphipathic alphahelix. NPY shares a 50 % amino acid homology with pancreatic polypeptide gene (PP). The NPY hormone family consists of NPY, PP and peptide YY. NPY is expressed throughout the central and peripheral nervous system, particularly in the deep layers of the cortex and smaller cell bodies in the white matter. NPY interacts with the Y-receptor family of G-protein coupled receptors. NPY interacts with NPY receptor Y1 to increase corticotropin levels and decrease noradrenaline levels in the hypothalamus. Through interactions in the hypothalus, NPY plays important roles in the regulation of energy balance by stimulating food intake. NPY favors energy storage by increasing lipoprotein lipase activity in white adipose tissue. A leucine(7)-to- proline(7) polymorphism has been implicated in an increase in alcohol preference, and decrease in cholesterol metabolism.
- Molecular Weight
- approx. 11 kDa
- Gene ID
- 4852
- NCBI Accession
- NP_000896
- UniProt
- P01303
- Pathways
- Feeding Behaviour
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