PRSS3 antibody

Catalog No. ABIN498692

Product Details anti-PRSS3 Antibody

Target: PRSS3 (Protease, serine, 3 (PRSS3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRSS3 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of Trypsin- 3 protein. (region surrounding Met166)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PRSS3

Target: PRSS3 (Protease, serine, 3 (PRSS3))

Alternative Name: Trypsin-3 / PRSS3 (PRSS3 Products)

Synonyms: MTG antibody, PRSS4 antibody, T9 antibody, TRY3 antibody, TRY4 antibody, Try3 antibody, Tb antibody, prss3 antibody, protease, serine 3 antibody, trypsin-3 antibody, protease, serine, 3 antibody, trypsin III antibody, protease, serine 3 L homeolog antibody, PRSS3 antibody, CpipJ_CPIJ016105 antibody, Prss3 antibody, trp-iii antibody, prss3.L antibody

Background: The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease Trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3 is expressed in the brain in addition to the pancreas.Synonyms: Brain trypsinogen, Mesotrypsinogen, PRSS4, Serine protease 3, Serine protease 4, TRY3, TRY4, Trypsin III, Trypsin IV

Molecular Weight: approx. 32 kDa

Gene ID: 5646

NCBI Accession: NP_002762

UniProt: P35030