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Crk antibody (pTyr221)

CRK Reactivity: Human, Mouse, Rat IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN498832
  • Target See all Crk (CRK) Antibodies
    Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
    Binding Specificity
    • 21
    • 15
    • 10
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr221
    Reactivity
    • 77
    • 21
    • 14
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 69
    • 8
    Rabbit
    Clonality
    • 69
    • 8
    Polyclonal
    Conjugate
    • 40
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This Crk antibody is un-conjugated
    Application
    • 62
    • 34
    • 27
    • 27
    • 15
    • 12
    • 8
    • 7
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of p-Crk2 protein only when phosphorylated at Try221.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Purity
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product CRK Primary Antibody
  • Application Notes
    Immunohistochemistry: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
    Alternative Name
    CRK (CRK Products)
    Synonyms
    CG1587 antibody, CRK antibody, D-CRK antibody, D-Crk antibody, DCrk antibody, Dcrk antibody, Dmel\\CG1587 antibody, crk antibody, dCRK antibody, dCrk antibody, fb34h10 antibody, fc05a01 antibody, fi19g05 antibody, wu:fb34h10 antibody, wu:fc05a01 antibody, wu:fc54a04 antibody, wu:fi19g05 antibody, zgc:100936 antibody, CRKII antibody, p38 antibody, Crko antibody, crk2 antibody, crkII antibody, v-crk antibody, P38C-CRK antibody, Crk-I antibody, Crk-II antibody, Crk-III antibody, Crk3 antibody, CrkIII antibody, c-Crk antibody, Crk oncogene antibody, v-crk avian sarcoma virus CT10 oncogene homolog antibody, CRK proto-oncogene, adaptor protein antibody, v-crk avian sarcoma virus CT10 oncogene homolog L homeolog antibody, v-crk sarcoma virus CT10 oncogene homolog antibody, Crk antibody, crk antibody, CRK antibody, crk.L antibody
    Background
    The Crk family of adapter proteins including Crk II, Crk I and Crk L consist mostly of SH2 and SH3 domains. Through the interactions between SH2 domain and phosphotyrosine residues and/or between SH3 domain and proline- rich motifs, they are involved in a variety of signaling cascades. Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities. Crk II has less transforming activity than Crk I, although both Crk I and Crk II bind to many tyrosine-phosphorylated proteins that bind to GRB2. In addition, Crk II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor-I (IGFI) and might be involved in the IGF-I receptor signalling pathway. The gene encoding Crk I and II maps to human chromosome 17p13, a region which demonstrates frequent deletion or loss of heterozygosity in a wide range of human cancers.Synonyms: Adapter molecule crk, Proto-oncogene C-crk, p38
    Molecular Weight
    approx. 42 kDa
    Gene ID
    1398
    NCBI Accession
    NP_005197
    UniProt
    P46108
    Pathways
    Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
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