FGFR1 antibody (pTyr154)

Catalog No. ABIN498838

Product Details anti-FGFR1 Antibody

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Binding Specificity: pTyr154

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of FGFR1 protein only when phosphorylated at Tyr154.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FGFR1

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Alternative Name: FGFR1 (FGFR1 Products)

Synonyms: FGFR antibody, fgfr antibody, X1FGFR antibody, XFGFR-1 antibody, XFGFRA2 antibody, bfgfr antibody, cek antibody, fgfr1 antibody, flg antibody, flt-2 antibody, flt2 antibody, kal2 antibody, ogd antibody, xfgfr1 antibody, CG7223 antibody, CT22273 antibody, CT39172 antibody, DFGF-R1 antibody, DFGF-R2 antibody, DFR-1 antibody, DFR1 antibody, DFR1/DFGF-R2 antibody, DPR3 antibody, DTRK(FR1) antibody, Dfr-1 antibody, Dfr1 antibody, DmHD-38 antibody, Dmel\\CG7223 antibody, Dtk1 antibody, EMS2 antibody, FGF-R2 antibody, FGFR2 antibody, FR1 antibody, Fr1 antibody, HD-38 antibody, HTL/FGFR1 antibody, Htl antibody, Tk1 antibody, dtk1 antibody, i100 antibody, i150 antibody, i79 antibody, j372 antibody, cd331 antibody, fgfbr antibody, fgfr-1 antibody, hbgfr antibody, n-sam antibody, ach antibody, cd333 antibody, cek2 antibody, fgfr-3 antibody, hsfgfr3ex antibody, jtk4 antibody, BFGFR antibody, CD331 antibody, CEK antibody, FGFBR antibody, FGFR-1 antibody, FLG antibody, FLT-2 antibody, FLT2 antibody, HBGFR antibody, HH2 antibody, KAL2 antibody, N-SAM antibody, OGD antibody, bFGF-R-1 antibody, AW208770 antibody, Eask antibody, Fgfr-1 antibody, Flt-2 antibody, Hspy antibody, FLG-1 antibody, FGFRI antibody, x1fgfr antibody, cb231 antibody, sb:cb231 antibody, fibroblast growth factor receptor antibody, fibroblast growth factor receptor 1 S homeolog antibody, basic fibroblast growth factor receptor 1 antibody, heartless antibody, fibroblast growth factor receptor 1 antibody, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog antibody, Fibroblast growth factor receptor 1 antibody, fibroblast growth factor receptor 1 L homeolog antibody, fibroblast growth factor receptor 1a antibody, FGFR antibody, fgfr antibody, fgfr1.S antibody, CpipJ_CPIJ005849 antibody, htl antibody, fgfr1 antibody, fgfr3.L antibody, FGFR1 antibody, Fgfr1 antibody, fgfr1.L antibody, fgfr1a antibody

Background: FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family and contains an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is widely expressed, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM.Synonyms: BFGFR, Basic fibroblast growth factor receptor 1, CEK, FGFBR, FLG, FLT-2, FLT2, Fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, HBGFR, N-sam, Proto-oncogene c-Fgr, bFGF-R-1

Molecular Weight: approx. 120,145 kDa

Gene ID: 2260

NCBI Accession: NP_056934

UniProt: P11362

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins