CDC42EP2 antibody

Catalog No. ABIN499043

Product Details anti-CDC42EP2 Antibody

Target: CDC42EP2 (CDC42 Effector Protein (Rho GTPase Binding) 2 (CDC42EP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC42EP2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of Cdc42EP2 protein. (region surrounding Leu24)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CDC42EP2

Target: CDC42EP2 (CDC42 Effector Protein (Rho GTPase Binding) 2 (CDC42EP2))

Alternative Name: CDC42EP2 (CDC42EP2 Products)

Synonyms: CDC42EP2 antibody, zgc:103557 antibody, BORG1 antibody, CEP2 antibody, 1110008C05Rik antibody, Borg1 antibody, Cep2 antibody, D19Bwg1013e antibody, CDC42 effector protein 2 antibody, CDC42 effector protein 2 S homeolog antibody, CDC42 effector protein (Rho GTPase binding) 2 antibody, CDC42EP2 antibody, cdc42ep2.S antibody, cdc42ep2 antibody, Cdc42ep2 antibody

Background: Cdc42, a small GTPase, regulates Actin polymerization, elongation of cell shape and cell signaling through interactions with many different downstream effector proteins, most of which contain a Cdc42-binding motif known as a CRIB domain. Cdc42EP2 (Cdc42 effector protein 2), also known as BORG1 or CEP2, is a 210 amino acid intracytoplasmic protein that localizes to both the cytoplasm and the cytoskeleton and contains one CRIB domain. Highly expressed in heart and present at lower levels in liver and pancreas, Cdc42EP2 interacts with Cdc42 and is thought to be involved in the organization of the Actin cytoskeleton and may also influence Actin filament assembly and overall cell shape.Synonyms: BORG1, Binder of Rho GTPases 1, CEP2, Cdc42 effector protein 2

Molecular Weight: approx. 30 kDa

Gene ID: 10435

NCBI Accession: NP_006770

UniProt: O14613

Pathways: Regulation of Actin Filament Polymerization