IFI16 antibody

Catalog No. ABIN499076

Product Details anti-IFI16 Antibody

Target: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFI16 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of IFI-16 protein. (region surrounding asn772)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for IFI16

Target: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Alternative Name: IFI16 / IFNGIP1 (IFI16 Products)

Synonyms: IFNGIP1 antibody, PYHIN2 antibody, IFI16 antibody, Ifitm3l antibody, Ifitml antibody, interferon gamma inducible protein 16 antibody, interferon induced transmembrane protein 2 antibody, myeloid cell nuclear differentiation antigen-like protein antibody, interferon-activable protein 203 antibody, IFI16 antibody, Ifitm2 antibody, LOC100156073 antibody, LOC488622 antibody, Ifi16 antibody

Background: Interferon-gamma inducible protein 16 (IFI16) belongs to the HIN-200 family of transcriptional regulator linked to cell cycle regulation and differentiation by modulating the activities of multiple transcriptional factors, such as p53 and Rb. The HIN-200 (hematopoeitic interferon-inducible nuclear antigens with 200 amino acid repeat) family members contain a DNA binding domain, a transcriptional regulatory domain, DAPIN/PAAD domain associated with interferon response and a binding domain for BRCA1. IFI16 may have a role in the regulation of hematopoeitic cell differentiation and also be involved in DNA repair since it becomes a component of the DNA repair multi-protein BASC complex after UV-induced DNA damage. IFI16 is strongly induced by gamma interferon in vivo.Synonyms: Gamma-interferon-inducible protein Ifi-16, IFI-16, Interferon-inducible myeloid differentiation transcriptional activator

Molecular Weight: approx. 88 kDa

Gene ID: 3428

NCBI Accession: NP_005522

UniProt: Q16666

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagy, Inflammasome