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AATF antibody

AATF Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499185
  • Target See all AATF Antibodies
    AATF (Apoptosis Antagonizing Transcription Factor (AATF))
    Reactivity
    • 45
    • 14
    • 11
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 43
    • 3
    • 1
    Rabbit
    Clonality
    • 43
    • 4
    Polyclonal
    Conjugate
    • 34
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AATF antibody is un-conjugated
    Application
    • 34
    • 21
    • 12
    • 8
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    AATF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human AATF.
    Purification
    Immunoaffinity purified IgG
    Immunogen
    Human AATF Peptide
    Isotype
    IgG
    Top Product
    Discover our top product AATF Primary Antibody
  • Application Notes
    ELISA. Western Blot: AATF antibody can be used for the detection of AATF at 0.5 - 1 μg/mL. Humansmall intestine cell lysate can be used as positive control. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    AATF (Apoptosis Antagonizing Transcription Factor (AATF))
    Alternative Name
    AATF (AATF Products)
    Synonyms
    AATF antibody, ded antibody, che1 antibody, che-1 antibody, cb109 antibody, sb:cb109 antibody, wu:fc13d05 antibody, zgc:162071 antibody, CHE-1 antibody, CHE1 antibody, DED antibody, 4933415H02Rik antibody, 5830465M17Rik antibody, Che-1 antibody, Trb antibody, Ded antibody, apoptosis antagonizing transcription factor antibody, Apoptosis antagonizing transcription factor antibody, apoptosis antagonizing transcription factor S homeolog antibody, AATF antibody, aatf antibody, BFR2 antibody, NAEGRDRAFT_56916 antibody, Aatf antibody, aatf.S antibody
    Background
    AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases (2). AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways (3). Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the b-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer's disease (AD) (4,5), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.Synonyms: Apoptosis-antagonizing transcription factor, CHE-1, CHE1, DED, HSPC277, Rb-binding protein Che-1
    Gene ID
    26574
    NCBI Accession
    NP_036270
    UniProt
    Q9NY61
    Pathways
    Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome
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