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AFAP1L2 antibody (C-Term)

AFAP1L2 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499229
  • Target See all AFAP1L2 Antibodies
    AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))
    Binding Specificity
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 19
    • 19
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 20
    • 2
    Rabbit
    Clonality
    • 20
    • 2
    Polyclonal
    Conjugate
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AFAP1L2 antibody is un-conjugated
    Application
    • 22
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This anitbody reacts to AFAP1L2.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    AFAP1L2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human AFAP1L2.
    Isotype
    IgG
    Top Product
    Discover our top product AFAP1L2 Primary Antibody
  • Application Notes
    ELISA. Western Blot: AFAP1L2 antibody can be used for detection of AFAP1L2 at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))
    Alternative Name
    AFAP1L2 (AFAP1L2 Products)
    Synonyms
    KIAA1914 antibody, XB130 antibody, AU041783 antibody, C86904 antibody, mKIAA1914 antibody, RGD1310668 antibody, actin filament associated protein 1 like 2 antibody, actin filament associated protein 1-like 2 antibody, AFAP1L2 antibody, Afap1l2 antibody
    Background
    AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3b, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.Synonyms: AFAP1-like protein 2, Actin filament-associated protein 1-like 2, KIAA1914, XB130
    Gene ID
    84632
    NCBI Accession
    NP_001001936
    UniProt
    Q8N4X5
    Pathways
    EGFR Signaling Pathway
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