AKIRIN2 antibody (Center)

Catalog No. ABIN499259

Product Details anti-AKIRIN2 Antibody

Target: AKIRIN2 (Akirin 2 (AKIRIN2))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKIRIN2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to AKIRIN-2.

Purification: Affinity chromatography purified via peptide column

Immunogen: Akirin2 antibody was raised against a 15 amino acid peptide near the center of the human Akirin2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Akirin2 antibody can be used for detection of Akirin2 at 0.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for AKIRIN2

Target: AKIRIN2 (Akirin 2 (AKIRIN2))

Alternative Name: AKIRIN2 / C6orf166 (AKIRIN2 Products)

Synonyms: MGC76154 antibody, c6orf166 antibody, C6orf166 antibody, wu:fb16h11 antibody, wu:fi04e05 antibody, zgc:114001 antibody, zgc:55291 antibody, zgc:77169 antibody, FBI1 antibody, dJ486L4.2 antibody, 2700059D21Rik antibody, AA114675 antibody, AA522011 antibody, AU019887 antibody, Akirin-2 antibody, RGD1307791 antibody, C9H6ORF166 antibody, akirin-2 antibody, akirin 2 antibody, akirin 2 S homeolog antibody, akirin2 antibody, akirin2.S antibody, AKIRIN2 antibody, Akirin2 antibody

Background: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.Synonyms: Akirin-2

Gene ID: 55122

UniProt: Q53H80

Pathways: Positive Regulation of Endopeptidase Activity