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AMBRA1 antibody (C-Term)

AMBRA1 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499271
  • Target See all AMBRA1 Antibodies
    AMBRA1 (Autophagy/beclin-1 Regulator 1 (AMBRA1))
    Binding Specificity
    • 21
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 40
    • 28
    • 12
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 54
    • 1
    Rabbit
    Clonality
    • 54
    • 1
    Polyclonal
    Conjugate
    • 15
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AMBRA1 antibody is un-conjugated
    Application
    • 47
    • 13
    • 13
    • 13
    • 11
    • 10
    • 9
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to AMBRA1.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Ambra1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human Ambra1.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western Blot: Ambra1 antibody can be used for the detection of Ambra1 at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    AMBRA1 (Autophagy/beclin-1 Regulator 1 (AMBRA1))
    Alternative Name
    AMBRA1 (AMBRA1 Products)
    Synonyms
    2310079H06Rik antibody, A130023A14 antibody, AA474864 antibody, AV021921 antibody, D030051N19Rik antibody, mKIAA1736 antibody, Nyw1 antibody, DCAF3 antibody, WDR94 antibody, autophagy and beclin 1 regulator 1 antibody, autophagy/beclin-1 regulator 1a antibody, autophagy/beclin 1 regulator 1 antibody, AMBRA1 antibody, ambra1a antibody, Ambra1 antibody
    Background
    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death . Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.Synonyms: Activating molecule in BECN1-regulated autophagy protein 1, KIAA1736
    Gene ID
    55626
    UniProt
    Q9C0C7
    Pathways
    Autophagy
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