APC1 antibody (C-Term)

Catalog No. ABIN499291

Product Details anti-APC1 Antibody

Target: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: APC1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human APC1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: APC1 antibody can be used for detection of APC1 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for APC1

Target: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Alternative Name: APC1 / ANAPC1 (ANAPC1 Products)

Synonyms: APC1 antibody, MCPR antibody, TSG24 antibody, DDBDRAFT_0186456 antibody, DDBDRAFT_0234263 antibody, DDB_0186456 antibody, DDB_0234263 antibody, 2610021O03Rik antibody, AI047775 antibody, AI853536 antibody, AW547281 antibody, Apc1 antibody, Mcpr antibody, tsg24 antibody, EMBRYO DEFECTIVE 2771 antibody, MOP10.10 antibody, MOP10_10 antibody, anaphase promoting complex subunit 1 antibody, E3 ubiquitin ligase antibody, ANAPC1 antibody, Anapc1 antibody, CC1G_09696 antibody, anapc1 antibody, EMB2771 antibody

Background: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.Synonyms: Anaphase-promoting complex subunit 1, Cyclosome subunit 1, MCPR, Mitotic checkpoint regulator, TSG24, Testis-specific gene 24 protein

Gene ID: 64682

UniProt: Q9H1A4