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ANAPC5 antibody (Anaphase Promoting Complex Subunit 5) (Center)

Details for Product anti-ANAPC5 Antibody No. ABIN499299, Supplier: Login to see New
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Synonyms DDBDRAFT_0206386, DDBDRAFT_0234269, DDB_0206386, DDB_0234269, zgc:55800, wu:fb75a09, ANAPC5, MGC89697, APC5, 2510006G12Rik, AA408751, AA536819, AA986414, Anpc5, F12K11.7, F12K11_7
(18), (17), (12), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(90), (32), (30)
(89), (1)
This ANAPC5 antibody is un-conjugated
(6), (6), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(69), (47), (30), (15), (11), (7), (5), (3), (2), (1)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen APC5 antibody was raised against a 17 amino acid peptide near the center of human APC5.
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name APC5 / ANAPC5 (ANAPC5 Antibody Abstract)
Background Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC5 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC5, it is thought that APC5 associates with other APC/C components APC1, APC4, and CDC23 interdependently, such that loss of any one subunit reduces binding between the remaining three.Synonyms: Anaphase-promoting complex subunit 5, Cyclosome subunit 5
Gene ID 51433
UniProt Q9UJX4
Research Area Coagulation
Application Notes ELISA. Western Blot: APC5 antibody can be used for detection of APC5 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-ANAPC5 antibody (Anaphase Promoting Complex Subunit 5) (Center) (ABIN499299) Western blot analysis of APC5 in human kidney tissue lysate with AP30061PU-N APC5 ant...
Background publications Peters: "The anaphase promoting complex/cyclosome: a machine designed to destroy." in: Nature reviews. Molecular cell biology, Vol. 7, Issue 9, pp. 644-56, 2006 (PubMed).

Thornton, Ng, Matyskiela et al.: "An architectural map of the anaphase-promoting complex." in: Genes & development, Vol. 20, Issue 4, pp. 449-60, 2006 (PubMed).

Jörgensen, Gräslund, Betz et al.: "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex." in: Gene, Vol. 262, Issue 1-2, pp. 51-9, 2001 (PubMed).

Catalog No. ABIN499299
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