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ARL6IP1 antibody (may play a role in hematopoetic maturation [RGD, Feb 2006]..") (C-Term)

Details for Product anti-ARL6IP1 Antibody No. ABIN499337, Supplier: Log in to see
Antigen
  • arl6ip
  • MGC56593
  • zgc:56593
  • zgc:77873
  • ARL6IP
  • aip1
  • armer
  • ARL6IP1
  • MGC85055
  • MGC139614
  • DKFZp459O112
  • AIP1
  • ARMER
  • AIP-6
  • AL022945
  • AU042858
  • Aip-1
  • Arl6ip
  • C85138
  • mKIAA0069
Epitope
C-Term
19
17
17
5
4
2
1
1
Reactivity
Human, Mouse (Murine)
56
16
9
Host
Rabbit
50
8
Clonality
Polyclonal
Conjugate
This ARL6IP1 antibody is un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
51
28
12
6
2
1
1
1
Supplier
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Immunogen Human ARMER / ARL6IP / AIP1 (C-Terminus) Peptide
Isotype IgG
Specificity ARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER.
Purification Ion exchange chromatography
Alternative Name ARL6IP1 (ARL6IP1 Antibody Abstract)
Background Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.Synonyms: ADP-ribosylation factor-like protein 6-interacting protein 1, ARL-6-interacting protein 1, Aip-1, KIAA0069
Gene ID 23204
UniProt Q15041
Application Notes ELISA. Western Blot: ARMER antibody can be used for detection of ARMER at 0.5 to 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-ARL6IP1 antibody (may play a role in hematopoetic maturation [RGD, Feb 2006].. Immunohistochemical staining of human bladder tissue using AP30081PU-N ARMER antibody...
Western Blotting (WB) image for anti-ARL6IP1 antibody (may play a role in hematopoetic maturation [RGD, Feb 2006].. Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with AP30081P...
Background publications Lui, Chen, Wang et al.: "ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis." in: Molecular cancer research : MCR, Vol. 1, Issue 7, pp. 508-18, 2003 (PubMed).

Nakagawa, Zhu, Morishima et al.: "Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta." in: Nature, Vol. 403, Issue 6765, pp. 98-103, 2000 (PubMed).

Steller: "Mechanisms and genes of cellular suicide." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1445-9, 1995 (PubMed).

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