ATOH8 antibody (C-Term)

Catalog No. ABIN499361

Product Details anti-ATOH8 Antibody

Target: ATOH8 (Atonal Homolog 8 (ATOH8))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATOH8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to ATOH8.

Purification: Affinity chromatography purified via peptide column

Immunogen: ATOH8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human ATOH8.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: ATOH8 antibody can be used for detection of ATOH8 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for ATOH8

Target: ATOH8 (Atonal Homolog 8 (ATOH8))

Alternative Name: ATOH8 (ATOH8 Products)

Synonyms: ath6 antibody, zgc:158314 antibody, ATOH8 antibody, HATH6 antibody, bHLHa21 antibody, 4933425C05Rik antibody, Hath6 antibody, Math6 antibody, okadin antibody, RGD1561512 antibody, atonal bHLH transcription factor 8 antibody, atoh8 antibody, ATOH8 antibody, Atoh8 antibody

Background: Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57 % identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.Synonyms: Helix-loop-helix protein hATH-6, Protein atonal homolog 8, hATH-6, hATH6

Gene ID: 84913

NCBI Accession: NP_116216

UniProt: Q96SQ7

Pathways: Regulation of Muscle Cell Differentiation