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Influenza A H5N1 (Intermediate Domain) antibody

Details for Product No. ABIN499381
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Antigen
Epitope
Intermediate Domain
(10), (4), (3), (3), (1)
Reactivity
Influenza A Virus H5N1
(35)
Host
Rabbit
(22), (9), (4)
Clonality
Polyclonal
Application
ELISA
(35), (9), (5), (5), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN499381
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Immunogen Avian Influenza Hemagglutinin (Intermediate Domain) Peptide (AP30105CP-N). Avian Influenza Hemagglutinin antibody was raised against a synthetic peptide corresponding to 14 amino acids in the middle of the avian influenza hemagglutinin protein. Efforts were made to use relatively conserved regions of the viral sequence as the antigen.
Isotype IgG
Specificity This antibody recognizes Avian Influenza Hemagglutinin.
Purification Affinity Chromatography purified via peptide column
Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, however it is in birds that all subtypes can be found (2). These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong (3). There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low (4). HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability (5).
Alternate names: Avian Influenza A H5N1 H5 Hemagglutinin
UniProt Q692M2
Application Notes Avian influenza hemagglutinin antibody can be used for the detection of the avianinfluenza hemagglutinin protein from the H5N1 strain of avian influenza A in ELISA. It willdetect 10 ng of free peptide at 1 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Shortridge, Zhou, Guan et al.: "Characterization of avian H5N1 influenza viruses from poultry in Hong Kong." in: Virology, Vol. 252, Issue 2, pp. 331-42, 1999 (PubMed).

Buxton Bridges, Katz, Seto et al.: "Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong." in: The Journal of infectious diseases, Vol. 181, Issue 1, pp. 344-8, 2000 (PubMed).

Alexander: "A review of avian influenza in different bird species." in: Veterinary microbiology, Vol. 74, Issue 1-2, pp. 3-13, 2000 (PubMed).

Thompson, Shay, Weintraub et al.: "Mortality associated with influenza and respiratory syncytial virus in the United States." in: JAMA : the journal of the American Medical Association, Vol. 289, Issue 2, pp. 179-86, 2003 (PubMed).

Iwatsuki-Horimoto, Kanazawa, Sugii et al.: "The index influenza A virus subtype H5N1 isolated from a human in 1997 differs in its receptor-binding properties from a virulent avian influenza virus." in: The Journal of general virology, Vol. 85, Issue Pt 4, pp. 1001-5, 2004 (PubMed).

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