Influenza A H5N1 (Intermediate Domain) antibody

Details for Product No. ABIN499385
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Antigen
Epitope
Intermediate Domain
(10), (4), (3), (3), (1)
Reactivity
Influenza A Virus H5N1
(35), (1)
Host
Rabbit
(23), (9), (4)
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA)
(35), (10), (5), (5), (5), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN499385
357.50 $
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Immunogen Avian Influenza Neuriminidase (Intermediate Domain) Peptide
Isotype IgG
Purification Affinity chromatography purified via peptide column
Target Type Virus
Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). Novel influenza virus strains emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, however it is in birds that all subtypes can be found (2). These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong (3). There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low (4). Although it has been known that cleavage site and glycosylation patterns of the HA protein play important roles in determining the pathogenicity of H5 avian influenza viruses, it has only recently been shown that an additional glycosylation site within the globular head of the NA protein also contributes to the high virulence of the H5N1 virus (5).Synonyms: Avian Influenza A H5N1 H5 Hemagglutinin
UniProt Q710U6
Application Notes Avian influenza neuriminidase antibody can be used for the detection of the avianinfluenza neuriminidase protein from the H5N1 strain of Avian influenza A in ELISA. It willdetect 10 ng of free peptide at 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Shortridge, Zhou, Guan et al.: "Characterization of avian H5N1 influenza viruses from poultry in Hong Kong." in: Virology, Vol. 252, Issue 2, pp. 331-42, 1999 (PubMed).

Buxton Bridges, Katz, Seto et al.: "Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong." in: The Journal of infectious diseases, Vol. 181, Issue 1, pp. 344-8, 2000 (PubMed).

Alexander: "A review of avian influenza in different bird species." in: Veterinary microbiology, Vol. 74, Issue 1-2, pp. 3-13, 2000 (PubMed).

Thompson, Shay, Weintraub et al.: "Mortality associated with influenza and respiratory syncytial virus in the United States." in: JAMA : the journal of the American Medical Association, Vol. 289, Issue 2, pp. 179-86, 2003 (PubMed).

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