You are viewing an incomplete version of our website. Please click to reload the website as full version.

TNFSF13B antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b) (C-Term)

Details for Product anti-TNFSF13B Antibody No. ABIN499401, Supplier: Log in to see
Antigen
  • BAFF
  • BLyS
  • BLYS
  • CD257
  • D8Ertd387e
  • DTL
  • RGD1561519
  • TALL-1
  • TALL1
  • THANK
  • TNFSF13B
  • TNFSF20
  • zTNF4
  • ZTNF4
Alternatives
anti-Human TNFSF13B antibody for Enzyme Immunoassay
Epitope
C-Term
18
17
16
15
13
13
9
6
5
5
4
3
3
3
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
255
58
35
Host
Rabbit
122
93
48
18
Clonality
Polyclonal
Conjugate
This TNFSF13B antibody is un-conjugated
25
21
8
8
7
4
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
164
133
70
43
26
21
14
12
11
8
4
3
3
2
2
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen A peptide corresponding to amino acids near the carboxy terminus of Human BAFF
Isotype IgG
Specificity Recognizes BAFF
Purification Ion Exchange Chromatography
Alternative Name CD257 / BAFF (TNFSF13B Antibody Abstract)
Background Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kappaB and c-jun N-terminal Kinase) (1-4). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R (5,6). BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis (5).Synonyms: B cell-activating factor, B lymphocyte stimulator, BAFF, BLYS, Dendritic cell-derived TNF-like molecule, TALL1, TNF- and APOL-related leukocyte expressed ligand 1, TNFSF13B, TNFSF20, Tumor necrosis factor ligand superfamily member 13B, ZTNF4
Gene ID 10673
NCBI Accession NP_006564
UniProt Q9Y275
Research Area Apoptosis/Necrosis
Pathways NF-kappaB Signaling
Application Notes ELISA. Western Blot: BAFF antibody can be used for detection of BAFF at 0.25 to 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-TNFSF13B antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b) (C-Term) (ABIN499401) Immunocytochemistry of BAFF in HL60 cells with AP30115PU-N BAFF antibody at 1 μg/ml.
Western Blotting (WB) image for anti-TNFSF13B antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b) (C-Term) (ABIN499401) Western blot analysis of BAFF in human HL60 cell lysate (H) and mouse spleen tissue l...
Background publications Schneider, MacKay, Steiner, Hofmann, Bodmer, Holler, Ambrose, Lawton, Bixler, Acha-Orbea, Valmori, Romero, Werner-Favre, Zubler, Browning, Tschopp: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).

Mukhopadhyay, Ni, Zhai, Yu, Aggarwal: "Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase." in: The Journal of biological chemistry, Vol. 274, Issue 23, pp. 15978-81, 1999 (PubMed).

Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).

Moore, Belvedere, Orr, Pieri, LaFleur, Feng, Soppet, Charters, Gentz, Parmelee, Li, Galperina, Giri, Roschke, Nardelli, Carrell, Sosnovtseva, Greenfield, Ruben, Olsen, Fikes, Hilbert: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).