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TNFRSF13C antibody (Tumor Necrosis Factor Receptor Superfamily, Member 13C) (C-Term)

Details for Product anti-TNFRSF13C Antibody No. ABIN499403, Supplier: Log in to see
Antigen
  • RGD1560810
  • TNFRSF13C
  • BAFF-R
  • BAFFR
  • BROMIX
  • CD268
  • CVID4
  • prolixin
  • 2010006P15Rik
  • Baffr
  • Bcmd
  • Bcmd-1
  • Bcmd1
  • Lvis22
Alternatives
anti-Human TNFRSF13C antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term
18
17
11
4
4
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
128
62
30
4
Host
Rabbit
85
59
28
Clonality
Polyclonal
Conjugate
This TNFRSF13C antibody is un-conjugated
16
11
9
6
4
4
3
3
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
79
72
50
24
22
11
10
7
7
5
4
2
2
1
1
1
1
Supplier
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Immunogen Human BAFF Receptor (C-Terminus) Peptide
Isotype IgG
Specificity BAFF Receptor antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of human BAFF Receptor The peptide sequence is identical between human and mouse origin.
Purification Affinity chromatography purified via peptide column
Alternative Name CD268 / BAFFR (TNFRSF13C Antibody Abstract)
Background Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4 (1-4). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). Two receptors, TACI and BCMA, for BAFF were originally identified (5). A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3 (6,7). Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase (4-6).Synonyms: B cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, BR3, TNFRSF13C, Tumor necrosis factor receptor superfamily member 13C
Gene ID 115650
UniProt Q96RJ3
Research Area Apoptosis/Necrosis, Receptors
Pathways NF-kappaB Signaling
Application Notes ELISA. Western Blot: BAFF Receptor antibody can be used for detection of BAFF Receptor at 2 to 5 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TNFRSF13C antibody (Tumor Necrosis Factor Receptor Superfamily, Member 13C) (C-Term) (ABIN499403) Immunohistochemistry of BAFF Receptor in human tonsil tissue with BAFF Receptor antib...
Western Blotting (WB) image for anti-TNFRSF13C antibody (Tumor Necrosis Factor Receptor Superfamily, Member 13C) (C-Term) (ABIN499403) Western blot analysis of BAFF Receptor in human (H), mouse (M), and rat (R) spleen ti...
Background publications Moore, Belvedere, Orr et al.: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).

Schneider, MacKay, Steiner et al.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).

Mukhopadhyay, Ni, Zhai et al.: "Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase." in: The Journal of biological chemistry, Vol. 274, Issue 23, pp. 15978-81, 1999 (PubMed).

Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).

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