BCL2A1 antibody (N-Term)

Catalog No. ABIN499453

Product Details anti-BCL2A1 Antibody

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2A1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to BFL-1.

Purification: Affinity chromatography purified via peptide column

Immunogen: Bfl-1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human Bfl-1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Bfl-1 antibody can be used for the detection of Bfl-1 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for BCL2A1

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Abstract: BCL2A1 Products

Synonyms: ACC-1 antibody, ACC-2 antibody, BCL2L5 antibody, BFL1 antibody, GRS antibody, HBPA1 antibody, Bcl2a1d antibody, BCL2A1 antibody, BCL2 related protein A1 antibody, BCL2-related protein A1 antibody, BCL2A1 antibody, Bcl2a1 antibody

Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist. Presumably due to post-translational modifications, Bfl-1 is often observed at higher molecular weight in SDS-PAGE than its predicted molecular weight would suggest.Synonyms: BCL2A1, BCL2L5, BFL1, Bcl-2-like protein 5, Bcl-2-related protein A1, GRS, HBPA1, Hemopoietic-specific early response protein, Protein BFL-1

Gene ID: 597

NCBI Accession: NP_004040

UniProt: Q16548