PRDM1 antibody (N-Term)

Catalog No. ABIN499477

Product Details anti-PRDM1 Antibody

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to Blimp-1.

Purification: Affinity chromatography purified via peptide column

Immunogen: Blimp-1 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Blimp-1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Blimp-1 antibody can be used for detection of Blimp-1 by Western blot at 0.5- 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for PRDM1

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Alternative Name: PRDM1 / BLIMP1 (PRDM1 Products)

Synonyms: GB11750 antibody, CG5249 antibody, Dmel\\CG5249 antibody, blimp-1 antibody, dBlimp-1 antibody, dBlimp1 antibody, Blimp-1 antibody, Blimp1 antibody, nrd antibody, prdm1 antibody, ubo antibody, wu:fb99c12 antibody, zgc:91885 antibody, MGC52536 antibody, PRDM1 antibody, blimp1 antibody, xblimp1 antibody, prdi-bf1 antibody, BLIMP1 antibody, PRDI-BF1 antibody, ZNFPR1A1 antibody, PR/SET domain 1 antibody, probable serine/threonine-protein kinase DDB_G0282963 antibody, CG5249 gene product from transcript CG5249-RF antibody, blimp-1 antibody, PR domain containing 1a, with ZNF domain antibody, PR domain 1 S homeolog antibody, B lymphocyte induced maturation protein 1 antibody, PR domain 1 antibody, PR domain containing 1, with ZNF domain antibody, PRDM1 antibody, LOC408295 antibody, Blimp-1 antibody, CpipJ_CPIJ007425 antibody, prdm1a antibody, prdm1.S antibody, prdm1 antibody, Prdm1 antibody

Background: Blimp-1 was initially identified as a zinc finger-containing protein that drives the maturation of B lymphocytes into immunoglobulin-secreting cells (1). Together with X-box-binding protein 1 (XBP1), Blimp-1 is induced upon terminal differentiation of plasma cells (2,3). The transcriptional repressor activity of Blimp-1 has also been found to regulate T cell homeostasis and function, possibly by suppressing the expression of the cytokines IL-2 and interferon-gamma during T cell development (4). More recent experiments have suggested that Blimp-1 also plays a major role in the formation of primordial germ cells (PGC) in developing mammalian embryos. In these experiments, Blimp-1-deficient mutant mouse embryos form a cluster of PGC-like cells which fail to show the expected migration, proliferation, and repression of homeobox genes that normally accompany specification of primordial germ cells (5). Blimp-1 exists as at least two different isoforms.Synonyms: BLIMP-1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain zinc finger protein 1, PR domain-containing protein 1, PRDI-BF1, PRDI-binding factor 1, Positive regulatory domain I-binding factor 1

Gene ID: 639

NCBI Accession: NP_001189

UniProt: O75626

Pathways: Regulation of Muscle Cell Differentiation