Calpain 6 antibody (C-Term)

Catalog No. ABIN499521

Product Details anti-Calpain 6 Antibody

Target: Calpain 6 (CAPN6)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CAPN6.

Purification: Affinity chromatography purified via peptide column

Immunogen: CAPN6 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human CAPN6.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CAPN6 antibody can be used for the detection of StrepII at 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for Calpain 6

Target: Calpain 6 (CAPN6)

Alternative Name: Calpain-6 (CAPN6 Products)

Synonyms: CAPN6 antibody, CANPX antibody, CAPNX antibody, CalpM antibody, DJ914P14.1 antibody, calpain 6 antibody, CAPN6 antibody, Capn6 antibody

Background: Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5, the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.Synonyms: CALPM, CANPX, CAPN6, Calpain-like protease X-linked, Calpamodulin

Gene ID: 827

NCBI Accession: NP_055104

UniProt: Q9Y6Q1