You are viewing an incomplete version of our website. Please click to reload the website as full version.

TBC1 Domain Family, Member 10C (TBC1D10C) (C-Term) antibody

Details for Product No. ABIN499529, Supplier: Log in to see
Antigen
  • 1810062O14Rik
  • AI428527
  • CARABIN
  • EPI64C
  • RGD1311490
Epitope
C-Term
18
7
4
Reactivity
Human, Mouse (Murine)
37
18
5
5
3
2
1
1
Host
Rabbit
31
7
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
32
22
16
6
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen Carabin antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Carabin.
Isotype IgG
Specificity This antibody reacts to Carabin.
Purification Affinity chromatography purified via peptide column
Alternative Name Carabin (TBC1D10C Antibody Abstract)
Background Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.Synonyms: TBC1 domain family member 10C, TBC1D10C
Gene ID 374403
NCBI Accession NP_940919
UniProt Q8IV04
Application Notes ELISA. Western Blot: Carabin antibody can be used for detection of Carabin at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TBC1 Domain Family, Member 10C (TBC1D10C) (C-Term) antibody (ABIN499529) Immunohistochemistry of Carabin in human spleen tissue with Carabin antibody at 2.5 μ...
Western Blotting (WB) image for anti-TBC1 Domain Family, Member 10C (TBC1D10C) (C-Term) antibody (ABIN499529) Western blot analysis of Carabin in Daudi cell lysate with AP30181PU-N Carabin antibo...
Background publications Pan, Sun, Kardian, Whartenby, Pardoll, Liu: "Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin." in: Nature, Vol. 445, Issue 7126, pp. 433-6, 2007 (PubMed).

Weil, Israël: "Deciphering the pathway from the TCR to NF-kappaB." in: Cell death and differentiation, Vol. 13, Issue 5, pp. 826-33, 2006 (PubMed).

Im, Rao: "Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling." in: Molecules and cells, Vol. 18, Issue 1, pp. 1-9, 2004 (PubMed).

White, Pasztor, Richardson, Zon: "The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4." in: Cytogenetics and cell genetics, Vol. 89, Issue 3-4, pp. 272-5, 2000 (PubMed).