Caspase 12 (CASP12) (N-Term) antibody

Details for Product No. ABIN499547
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms Caspase-12
(15), (14), (13), (12), (11), (9), (9), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(111), (91), (72)
(128), (13), (11)
(4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(138), (65), (55), (38), (16), (13), (10), (8), (6), (5), (3), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Mouse Caspase-12 (N-Terminus) Peptide
Isotype IgG
Specificity Caspase-12 antibody was raised against a peptide corresponding to amino acids 2 to 17 of murine caspase-12.
Purification Affinity chromatography purified via peptide column
Alternative Name Caspase-12 (CASP12 Antibody Abstract)
Background Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer\'s disease including g-secretase presenilin and b-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues (1).Synonyms: CASP-12, CASP12, Inactive caspase-12
Gene ID 100044205
UniProt O08736
Research Area Apoptosis/Necrosis
Application Notes ELISA. Western Blot: Caspase-12 antibody can be used for detection of caspase-12 at 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 12 (CASP12) (N-Term) antibody (ABIN499547) Immunohistochemistry of caspase-12 in human heart tissue with AP30190PU-N caspase-12 ...
Western Blotting (WB) image for anti-Caspase 12 (CASP12) (N-Term) antibody (ABIN499547) Western blot analysis of caspase-12 in human (A) and mouse (B) spleen tissue lysates ...
Background publications Nakagawa, Zhu, Morishima et al.: "Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta." in: Nature, Vol. 403, Issue 6765, pp. 98-103, 2000 (PubMed).

Mehmet: "Caspases find a new place to hide." in: Nature, Vol. 403, Issue 6765, pp. 29-30, 2000 (PubMed).

Van de Craen, Vandenabeele, Declercq et al.: "Characterization of seven murine caspase family members." in: FEBS letters, Vol. 403, Issue 1, pp. 61-9, 1997 (PubMed).

Catalog No. ABIN499547
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)
Did you look for something else?