Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (Intermediate Domain) antibody

Details for Product No. ABIN499563
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Antigen
Synonyms CASP4, ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX, Casp11, Caspl, ich-3, CASP1, CASP13
Epitope
Intermediate Domain
(24), (13), (8), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(109), (62), (34), (12), (5), (2)
Host
Rabbit
(118), (11), (8), (5), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(124), (51), (41), (32), (19), (15), (15), (4), (3), (2)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN499563
401.50 $
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Immunogen Human Casp-4 / ICH-2 / ICE rel II / Mih1 (Intermediate Domain) Peptide
Isotype IgG
Specificity Caspase-4 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-4.
Purification Affinity chromatography purified via peptide column
Alternative Name Caspase-4
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimers disease (5).
Alternate names: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX
Gene ID 837
UniProt P49662
Research Area Apoptosis/Necrosis
Application Notes ELISA. Western Blot: Casp-4 antibody can be used for the detection of Caspase-4 at 2 μg/ml. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Kuida, Lippke, Ku et al.: "Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme." in: Science (New York, N.Y.), Vol. 267, Issue 5206, pp. 2000-3, 1995 (PubMed).

Kamens, Paskind, Hugunin et al.: "Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases." in: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 15250-6, 1995 (PubMed).

Gracie, Robertson, McInnes: "Interleukin-18." in: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, 2003 (PubMed).

Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).

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