Cathelicidin antibody (C-Term)

Catalog No. ABIN499581

Product Details anti-Cathelicidin Antibody

Target: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathelicidin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Cathelicidin.

Purification: Peptide Affinity Chromatography

Immunogen: Cathelicidin antibody was raised against a 17 amino acid peptide near the carboxy terminus of the Human Cathelicidin.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Cathelicidin antibody can be used for detection of Cathelicidin at 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for Cathelicidin

Target: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Alternative Name: CAMP / CAP18 (CAMP Products)

Synonyms: CAP-18 antibody, CAP18 antibody, CRAMP antibody, FALL-39 antibody, FALL39 antibody, LL37 antibody, CATH-2 antibody, Cnlp antibody, Cramp antibody, MCLP antibody, CATH-B1 antibody, CATHB1 antibody, CATHL2 antibody, CATHL7 antibody, CAP11 antibody, cathelicidin antimicrobial peptide antibody, CAMP antibody, LOC100136187 antibody, LOC100136439 antibody, Camp antibody

Background: One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.Synonyms: 18 kDa cationic antimicrobial protein, Antibacterial protein LL-37, CAP-18, Cathelicidin antimicrobial peptide, FALL-39, FALL39, HSD26, hCAP-18

Gene ID: 820

NCBI Accession: NP_004336

UniProt: P49913

Pathways: Cellular Response to Molecule of Bacterial Origin