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CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4) (Extracellular Loop)

Details for Product anti-CXCR4 Antibody No. ABIN499698, Supplier: Log in to see
Antigen
  • cb403
  • cd184
  • CD184
  • Cmkar4
  • CXC-R4
  • CXC-R4-B
  • CXCR-4
  • CXCR-4-B
  • cxcr4
  • CXCR4
  • d2s201e
  • D2S201E
  • FB22
  • fb22
  • HM89
  • hm89
  • HSY3RR
  • hsy3rr
  • lap3
  • LAP3
  • lcr1
  • LCR1
  • LESTR
  • lestr
  • NPY3R
  • npy3r
  • npyr
  • NPYR
  • npyrl
  • NPYRL
  • npyy3r
  • NPYY3R
  • PB-CKR
  • PBSF/SDF-1
  • Sdf1r
  • WHIM
  • whim
  • xcxcr4
  • zgc:109863
Epitope
Extracellular Loop
89
29
14
14
14
13
12
12
10
10
8
7
6
5
5
5
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
356
161
74
13
8
5
5
4
4
4
3
2
2
2
1
1
Host
Rabbit
233
122
55
28
2
Clonality
Polyclonal
Conjugate
This CXCR4 antibody is un-conjugated
18
11
9
9
8
8
7
7
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
233
186
111
100
71
62
46
42
41
40
33
12
9
7
7
3
2
2
2
2
2
2
1
1
Supplier
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Immunogen Human CXCR4 (Extracellular Loop) Peptide
Isotype IgG
Specificity CXCR4 antibody was raised against a peptide corresponding to amino acids 182 to 196 in the second extracellular loop (EL) of human CXCR4.
Purification DEAE
Alternative Name CD184 / CXCR4 (CXCR4 Antibody Abstract)
Background Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.Synonyms: C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, NPYRL, SDF1 receptor, Stromal cell-derived factor 1 receptor
Gene ID 7852
NCBI Accession NP_003458
UniProt P61073
Research Area CD Antigens, Surface Receptors of Immune Cells, Chemokines, Receptors
Application Notes ELISA. Western Blot: 1/500 to 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Western Blotting (WB) image for anti-CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4) (Extracellular Loop) (ABIN499698) Western blot analysis of CXCR4 in HeLa total cell lysate with AP30267PU-N anti-CXCR4 ...
Background publications Dimitrov: "How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity." in: Cell, Vol. 91, Issue 6, pp. 721-30, 1998

Berson, Long, Doranz, Rucker, Jirik, Doms: "A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains." in: Journal of virology, Vol. 70, Issue 9, pp. 6288-95, 1996

Feng, Broder, Kennedy, Berger: "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor." in: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 872-7, 1996

Doranz, Rucker, Yi, Smyth, Samson, Peiper, Parmentier, Collman, Doms: "A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors." in: Cell, Vol. 85, Issue 7, pp. 1149-58, 1996