DACT3 antibody (N-Term)

Catalog No. ABIN499704

Product Details anti-DACT3 Antibody

Target: DACT3 (Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DACT3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to DACT3.

Purification: Affinity chromatography purified via peptide column

Immunogen: Dact3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Dact3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for DACT3

Target: DACT3 (Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3))

Alternative Name: DACT3 (DACT3 Products)

Synonyms: EG666671 antibody, naa-3 antibody, DAPPER3 antibody, RRR1 antibody, RGD1563892 antibody, dishevelled binding antagonist of beta catenin 3 antibody, dishevelled-binding antagonist of beta-catenin 3 antibody, DACT3 antibody, Dact3 antibody

Background: The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/b-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.Synonyms: DAPPER3, RRR1, antagonist of beta-catenin dapper homolog 3, arginine-rich region 1 protein, dapper homolog 3

Gene ID: 147906

UniProt: Q96B18