You are viewing an incomplete version of our website. Please click to reload the website as full version.

Death-Domain Associated Protein (DAXX) (C-Term) antibody

Details for Product No. ABIN499714, Supplier: Log in to see
Antigen
  • im:6905684
  • LOC100226911
  • BING2
  • DAP6
  • EAP1
  • death associated protein 3
  • death-domain associated protein
  • Fas death domain-associated protein
  • dap3
  • LOC100226911
  • DAP3
  • DAXX
  • Daxx
Alternatives
anti-Human Death-Domain Associated Protein antibody for Immunocytochemistry
Epitope
C-Term
60
32
29
23
18
15
15
15
12
6
6
4
4
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
304
93
79
16
4
3
3
2
2
2
2
1
1
1
1
Host
Rabbit
223
83
Clonality
Polyclonal
Conjugate
Un-conjugated
10
10
10
8
8
6
6
6
6
6
6
6
6
6
5
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
220
82
78
73
57
50
44
28
12
8
7
4
4
4
2
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen Human Daxx (C-Terminus) Peptide
Isotype IgG
Specificity Daxx antibody was raised against a peptide corresponding to amino acids near the carboxy-terminus of human Daxx.
Purification DEAE
Alternative Name DAXX (DAXX Antibody Abstract)
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.Synonyms: BING2, DAP6, Death domain-associated protein 6, EAP1, ETS1-associated protein 1, Fas death domain-associated protein
Gene ID 1616
NCBI Accession NP_001135441
UniProt Q9UER7
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway
Application Notes ELISA. Western Blot: 1-2 μg/mL. A 120 kDa major band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunofluorescence (IF) image for anti-Death-Domain Associated Protein (DAXX) (C-Term) antibody (ABIN499714) Immunocytochemistry of DAXX in HeLa cells with AP30275PU-N DAXX antibody at 10 μg/ml.
Western Blotting (WB) image for anti-Death-Domain Associated Protein (DAXX) (C-Term) antibody (ABIN499714) Western blot analysis of Daxx in 293 total cell lysate with AP30275PU-N Dax antibody ...
Background publications Kiriakidou, Driscoll, Lopez-Guisa, Strauss: "Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region." in: DNA and cell biology, Vol. 16, Issue 11, pp. 1289-98, 1998 (PubMed).

Yang, Khosravi-Far, Chang, Baltimore: "Daxx, a novel Fas-binding protein that activates JNK and apoptosis." in: Cell, Vol. 89, Issue 7, pp. 1067-76, 1997 (PubMed).