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Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 249-263), (Intracellular) antibody

Details for Product No. ABIN499724
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Antigen
Synonyms TNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD
Epitope
AA 249-263, Intracellular
(13), (6), (6), (5), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(105), (1)
Host
Rabbit
(75), (27), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (6), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(65), (43), (39), (15), (14), (7), (6), (5), (4), (2), (1)
Pubmed 6 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN499724
401.50 $
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Immunogen Human DcR2 (Intracellular Domain) Peptide (AP30280CP-N) corresponding to amino acids 249 to 263 of Human DcR2 precursor.
Isotype IgG
Specificity DcR2 antibody was raised against a peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.
Purification Affinity Chromatography purified via peptide column
Alternative Name CD264 / TRAILR4
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.
Alternate names: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D
Gene ID 8793
NCBI Accession Q9UBN6
UniProt Q9UBN6
Research Area Signaling, Apoptosis/Necrosis
Application Notes ELISA. Western Blot: 1/1000 to 1/2000. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Pan, ORourke, Chinnaiyan et al.: "The receptor for the cytotoxic ligand TRAIL." in: Science (New York, N.Y.), Vol. 276, Issue 5309, pp. 111-3, 1997 (PubMed).

Pan, Ni, Wei et al.: "An antagonist decoy receptor and a death domain-containing receptor for TRAIL." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 815-8, 1997 (PubMed).

Sheridan, Marsters, Pitti et al.: "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 818-21, 1997 (PubMed).

Marsters, Sheridan, Pitti et al.: "A novel receptor for Apo2L/TRAIL contains a truncated death domain." in: Current biology : CB, Vol. 7, Issue 12, pp. 1003-6, 1998 (PubMed).

Degli-Esposti, Dougall, Smolak et al.: "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain." in: Immunity, Vol. 7, Issue 6, pp. 813-20, 1998 (PubMed).

Pan, Ni, Yu et al.: "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling." in: FEBS letters, Vol. 424, Issue 1-2, pp. 41-5, 1998 (PubMed).

Validation Images
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