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DcR2 antibody (Intracellular)

TNFRSF10D Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499724
  • Target See all DcR2 (TNFRSF10D) Antibodies
    DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
    Binding Specificity
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 249-263, Intracellular
    Reactivity
    • 80
    • 7
    • 5
    • 1
    Human, Mouse, Rat
    Host
    • 64
    • 16
    Rabbit
    Clonality
    • 63
    • 17
    Polyclonal
    Conjugate
    • 35
    • 7
    • 7
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DcR2 antibody is un-conjugated
    Application
    • 60
    • 40
    • 23
    • 13
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    DcR2 antibody was raised against a peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.
    Purification
    Affinity Chromatography purified via peptide column
    Immunogen
    Human DcR2 (Intracellular Domain) Peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.
    Isotype
    IgG
    Top Product
    Discover our top product TNFRSF10D Primary Antibody
  • Application Notes
    ELISA. Western Blot: 1/1000 to 1/2000. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Liu, Hawkins, Vilgelm, Pawlikowski, Ecsedy, Sosman, Kelley, Richmond: "Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 21, Issue 23, pp. 5338-48, (2015) (PubMed).

  • Target
    DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
    Alternative Name
    CD264 / TRAILR4 (TNFRSF10D Products)
    Synonyms
    TNFRSF10D antibody, CD264 antibody, DCR2 antibody, TRAIL-R4 antibody, TRAILR4 antibody, TRUNDD antibody, TNF receptor superfamily member 10d antibody, tumor necrosis factor receptor superfamily member 10D antibody, TNFRSF10D antibody, LOC716901 antibody
    Background
    Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D
    Gene ID
    8793
    UniProt
    Q9UBN6
    Pathways
    Apoptosis
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