DISC1 antibody (Center)

Catalog No. ABIN499748

Product Details anti-DISC1 Antibody

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to DISC1.

Purification: Affinity chromatography purified via peptide column

Immunogen: DISC1 antibody was raised against a 18 amino acid peptide from near the center of human DISC1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for DISC1

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Alternative Name: DISC1 (DISC1 Products)

Synonyms: DISC1 antibody, C1orf136 antibody, SCZD9 antibody, disrupted in schizophrenia 1 antibody, disrupted in schizophrenia 1 protein antibody, disc1 antibody, DISC1 antibody, LOC100580606 antibody, Disc1 antibody

Background: Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3e from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.Synonyms: DISC-1, Disrupted in schizophrenia 1 protein, KIAA0457

Gene ID: 27185

NCBI Accession: NP_061132

UniProt: Q9NRI5

Pathways: Regulation of Cell Size