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FAM120A antibody (Center)

FAM120A Reactivity: Human, Mouse, Rat WB, IF, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499822
  • Target See all FAM120A Antibodies
    FAM120A (Family with Sequence Similarity 120A (FAM120A))
    Binding Specificity
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 9
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 8
    • 1
    Rabbit
    Clonality
    • 8
    • 1
    Polyclonal
    Conjugate
    • 9
    This FAM120A antibody is un-conjugated
    Application
    • 9
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to FAM120A.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    FAM120A antibody was raised against an 18 amino acid peptide from near the center of human FAM120A.
    Isotype
    IgG
    Top Product
    Discover our top product FAM120A Primary Antibody
  • Application Notes
    ELISA. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    FAM120A (Family with Sequence Similarity 120A (FAM120A))
    Alternative Name
    FAM120A (FAM120A Products)
    Synonyms
    MGC89333 antibody, fam120a antibody, C9orf10 antibody, Ossa antibody, DNAPTP1 antibody, DNAPTP5 antibody, OSSA antibody, RGD1306643 antibody, family with sequence similarity 120A antibody, family with sequence similarity 120, member A antibody, fam120a antibody, Fam120a antibody, FAM120A antibody
    Background
    FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR gamma family and the gene was mapped to chromosome 9q22.31. FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.Synonyms: C9orf10, Constitutive coactivator of PPAR-gamma-like protein 1, KIAA0183, OSSA, Oxidative stress-associated Src activator, Protein FAM120A
    Gene ID
    23196
    NCBI Accession
    NP_055427
    UniProt
    Q9NZB2
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