FEZ1 antibody (C-Term)

Catalog No. ABIN499830

Product Details anti-FEZ1 Antibody

Target: FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FEZ1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to FEZ1.

Purification: Affinity chromatography purified via peptide column

Immunogen: FEZ1 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human FEZ1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for FEZ1

Target: FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))

Alternative Name: Zygin-1 (FEZ1 Products)

Synonyms: UNC-76 antibody, UNC76 antibody, wu:fj14c12 antibody, zgc:73258 antibody, fez1 antibody, xfez1 antibody, fasciculation and elongation protein zeta 1 antibody, fasciculation and elongation protein zeta 1 (zygin I) antibody, fasciculation and elongation protein zeta 1 L homeolog antibody, FEZ1 antibody, Fez1 antibody, fez1 antibody, fez1.L antibody

Background: Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist. Despite its predicted molecular weight, FEZ1 will often run at higher molecular weight in SDS-PAGE.Synonyms: FEZ1, Fasciculation and elongation protein zeta-1, Zygin I

Gene ID: 9638

UniProt: Q99689