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FRMPD4 antibody (Center)

FRMPD4 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499861
  • Target See all FRMPD4 Antibodies
    FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))
    Binding Specificity
    • 1
    • 1
    Center
    Reactivity
    Human
    Host
    • 1
    • 1
    Rabbit
    Clonality
    • 1
    • 1
    Polyclonal
    Conjugate
    • 2
    This FRMPD4 antibody is un-conjugated
    Application
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    FRMPD4 antibody was raised against an 18 amino acid peptide from near the center of human FRMPD4.
    Isotype
    IgG
  • Application Notes
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))
    Alternative Name
    FRMPD4 (FRMPD4 Products)
    Synonyms
    RGD1566031 antibody, PDZD10 antibody, PDZK10 antibody, Gm196 antibody, PKAP1 antibody, Pdzd10 antibody, Pdzk10 antibody, Preso1 antibody, FERM and PDZ domain containing 4 antibody, Frmpd4 antibody, FRMPD4 antibody, frmpd4 antibody
    Background
    The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width, conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.Synonyms: FERM and PDZ domain-containing protein 4, KIAA0316, PDZ domain-containing protein 10, PDZD10, PDZK10, PSD-95-interacting regulator of spine morphogenesis, Preso
    Gene ID
    9758
    NCBI Accession
    NP_055543
    UniProt
    Q14CM0
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