Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (Intermediate Domain) antibody

Details for Product No. ABIN499883
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Antigen
Synonyms AU042498
Epitope
Intermediate Domain
(5), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(17), (3), (3)
Host
Rabbit
(9), (8)
Clonality
Polyclonal
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(12), (7), (2), (1), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN499883
Quantity 0.1 mg
Price
401.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human GFR alpha 1 (Intermediate Domain) Peptide (AP30361CP-N)
Isotype IgG
Specificity GFR alpha 1 antibody was raised against a peptide corresponding to amino acids 369 to 382 of human GFR alpha 1.
Purification DEAE Chromatography
Alternative Name GFRA1 / GDNFR-alpha
Background Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently. GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
Alternate names: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1
Gene ID 2674
NCBI Accession P56159
UniProt P56159
Application Notes ELISA. Western Blot. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Treanor, Goodman, de Sauvage et al.: "Characterization of a multicomponent receptor for GDNF." in: Nature, Vol. 382, Issue 6586, pp. 80-3, 1996 (PubMed).

Jing, Wen, Yu et al.: "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF." in: Cell, Vol. 85, Issue 7, pp. 1113-24, 1996 (PubMed).

Sanicola, Hession, Worley et al.: "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 12, pp. 6238-43, 1997 (PubMed).

Buj-Bello, Adu, Piñón et al.: "Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase." in: Nature, Vol. 387, Issue 6634, pp. 721-4, 1997 (PubMed).

Hosts (9), (8)
Reactivities (17), (3), (3)
Applications (12), (7), (2), (1), (1), (1), (1)
Epitopes (5), (2), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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