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IKAP/p150 antibody (C-Term)

ELP1 Reactivity: Human, Mouse WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499964
  • Target See all IKAP/p150 (ELP1) Antibodies
    IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
    Binding Specificity
    • 15
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 24
    • 24
    • 19
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 39
    • 3
    • 3
    Rabbit
    Clonality
    • 42
    • 3
    Polyclonal
    Conjugate
    • 18
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This IKAP/p150 antibody is un-conjugated
    Application
    • 35
    • 19
    • 13
    • 13
    • 9
    • 5
    • 5
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to IKAP.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    IKAP antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IKAP.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western Blot: 0.5 to 1 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
    Alternative Name
    ELP1 / IKBKAP (ELP1 Products)
    Synonyms
    DYS antibody, ELP1 antibody, FD antibody, IKAP antibody, IKI3 antibody, TOT1 antibody, IKBKAP antibody, DKFZp469N1415 antibody, 3110040G09Rik antibody, 6030413P05 antibody, C78473 antibody, Elp1 antibody, Ikbkap antibody, elongator complex protein 1 antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein antibody, ielongator complex protein 1 S homeolog antibody, inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein antibody, ELP1 antibody, Elp1 antibody, IKBKAP antibody, elp1.S antibody, elp1 antibody, Ikbkap antibody
    Background
    IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKalpha, IKKbeta, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.Synonyms: Elongator complex protein 1, IKAP, IKK complex-associated protein, IkappaB kinase complex-associated protein, p150
    Gene ID
    8518
    UniProt
    O95163
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