IKBKB antibody (C-Term)

Catalog No. ABIN499972

Product Details anti-IKBKB Antibody

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKBKB antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: IKK beta antibody was raised against a peptide corresponding to amino acids near the carboxy-terminus of human IKK beta (Genbank accession NoO14920), which differs from corresponding murine sequence by one amino acid. This polyclonal antibody has no cross response to IKKa or IKKy.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human IKK beta (C-Terminus 3) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Wesern Blot: 1 - 2 μg/mL. A 87 kDa band should be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IKBKB

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Alternative Name: IKBKB / IKKB (IKBKB Products)

Synonyms: ikk-beta antibody, ikk2 antibody, ikkb antibody, ikkbeta antibody, IKBKB antibody, IKKB antibody, CG4201 antibody, DIK antibody, DLAK antibody, DmIKK antibody, DmIKKBeta antibody, DmIKKb antibody, DmIKKbeta antibody, DmIkkbeta antibody, Dmel\\CG4201 antibody, Dmikkb antibody, Dmikkbeta antibody, IK antibody, IKK antibody, IKK-beta antibody, IKKb antibody, IKKbeta antibody, IRD-5 antibody, IRD5 antibody, Ik antibody, Ikkb antibody, Ikkbeta antibody, Ird-5 antibody, Ird5 antibody, LRK antibody, Lak antibody, anon-89Bd antibody, dIKK antibody, dIKK-beta antibody, dIKKbeta antibody, dLak antibody, dmIKKbeta antibody, ikk antibody, ird antibody, ird5/DmIkk[beta] antibody, IKK2 antibody, NFKBIKB antibody, AIM-1 antibody, AI132552 antibody, IKK-2 antibody, IKK[b] antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog antibody, inhibitor of nuclear factor kappa B kinase subunit beta antibody, I-kappaB kinase beta antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antibody, inhibitor of kappaB kinase beta antibody, ikbkb.L antibody, IKBKB antibody, ikbkb antibody, IKKbeta antibody, Ikbkb antibody

Background: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, and bacteria product LPS. NF-kappaB is associated with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The long-sought IkappaB kinase (IKK), which phosphorylates IkappaB, and mediates IkappaB degradation and NF-kappaB activation, was recently identified by several laboratories (1-5). IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKalpha and IKKbeta). IKKalpha and IKKbeta interact with each other and both are essential for NF-kappaB activation. IKKbeta phosphorylates both IkappaB-alpha and IkappaB-beta. IKKbeta is expressed in variety of human tissues.Synonyms: I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, IKK-beta, IKK2, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta

Gene ID: 3551

UniProt: O14920

Pathways: NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins