Interleukin 27 (IL27) (Center) antibody

Details for Product No. ABIN500002
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Antigen
Synonyms IL27, IL-17D, IL-22, IL-27, IL-27A, IL27A, IL27p28, IL30, p28, IL-27p28, Il30, RGD1561420
Epitope
Center
(5), (5), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(38), (35), (2), (1), (1)
Host
Rabbit
(49), (15), (5), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (4), (3), (3), (2), (2)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(61), (28), (9), (6), (6), (4), (4), (4), (4), (3), (3), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN500002
357.50 $
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Immunogen IL-27 antibody was raised against a 14 amino acid peptide from near the center of human IL-27.
Isotype IgG
Specificity This antibody reacts to IL-27.
Purification Affinity chromatography purified via peptide column
Alternative Name Interleukin-27 / IL27A
Background Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-γ, and T-bet.Synonyms: IL-27 subunit alpha, IL-30, IL27-A, IL30, Interleukin-30, p28
Gene ID 246778
NCBI Accession NP_663634
UniProt Q8NEV9
Application Notes ELISA. Western Blot: 2 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Pflanz, Timans, Cheung et al.: "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells." in: Immunity, Vol. 16, Issue 6, pp. 779-90, 2002 (PubMed).

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