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IL-31 antibody (Intermediate Domain)

IL31 Reactivity: Human, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500006
  • Target See all IL-31 (IL31) Antibodies
    IL-31 (IL31) (Interleukin 31 (IL31))
    Binding Specificity
    • 15
    • 13
    • 10
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intermediate Domain
    Reactivity
    • 56
    • 9
    • 8
    Human, Mouse
    Host
    • 51
    • 18
    Rabbit
    Clonality
    • 51
    • 18
    Polyclonal
    Conjugate
    • 31
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL-31 antibody is un-conjugated
    Application
    • 37
    • 30
    • 22
    • 14
    • 14
    • 14
    • 10
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    IL-31 antibody was raised against a 18 amino acid peptide from near the center of human IL-31.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Human IL-31 (Intermediate Domain) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product IL31 Primary Antibody
  • Application Notes
    ELISA. Western Blot: 2.5 - 5 μg/mL. Despite its predicted size, IL-31 runs at approximately 27 - 30 kDa in SDS-PAGE.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
  • Target
    IL-31 (IL31) (Interleukin 31 (IL31))
    Alternative Name
    Interleukin-31 / IL31 (IL31 Products)
    Synonyms
    IL-31 antibody, 1700013B14Rik antibody, IL31 antibody, interleukin 31 antibody, IL31 antibody, Il31 antibody
    Background
    Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).Synonyms: IL-31
    Gene ID
    386653
    NCBI Accession
    NP_001014358
    UniProt
    Q6EBC2
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