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IRF3 antibody (C-Term)

IRF3 Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500054
  • Target See all IRF3 Antibodies
    IRF3 (Interferon Regulatory Factor 3 (IRF3))
    Binding Specificity
    • 18
    • 16
    • 15
    • 14
    • 13
    • 9
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 144
    • 91
    • 57
    • 31
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 154
    • 13
    • 2
    Rabbit
    Clonality
    • 136
    • 33
    Polyclonal
    Conjugate
    • 90
    • 12
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This IRF3 antibody is un-conjugated
    Application
    • 123
    • 69
    • 33
    • 32
    • 29
    • 27
    • 19
    • 12
    • 10
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    IRF3 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF3.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Human IRF3 (C-Terminus) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product IRF3 Primary Antibody
  • Application Notes
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    IRF3 (Interferon Regulatory Factor 3 (IRF3))
    Alternative Name
    IRF3 (IRF3 Products)
    Synonyms
    irf3 antibody, IRF3 antibody, C920001K05Rik antibody, IRF-3 antibody, interferon regulatory factor 3 antibody, interferon regulatory factor 7 antibody, irf3 antibody, IRF3 antibody, irf-3 antibody, Irf3 antibody, IRF7 antibody
    Background
    Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells (2). Following viral infection, IRF3 can be activated by IkappaB kinase-epsilon and TANK-binding kinase 1 (TBK1) (3,4), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA (3,5). IRF3 exists as at least two distinct isoforms.Synonyms: IRF-3, Interferon regulatory factor 3
    Gene ID
    3661
    NCBI Accession
    NP_001562
    UniProt
    Q14653
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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