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Junctophilin 2 antibody (C-Term)

JPH2 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500096
  • Target See all Junctophilin 2 (JPH2) Antibodies
    Junctophilin 2 (JPH2)
    Binding Specificity
    • 8
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 42
    • 24
    • 24
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 39
    • 6
    Rabbit
    Clonality
    • 39
    • 6
    Polyclonal
    Conjugate
    • 21
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Junctophilin 2 antibody is un-conjugated
    Application
    • 45
    • 17
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects JPH2 at C-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    JPH2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human JPH2.
    Isotype
    IgG
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    Discover our top product JPH2 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    Junctophilin 2 (JPH2)
    Alternative Name
    Junctophilin-2 / JPH2 (JPH2 Products)
    Synonyms
    CMH17 antibody, JP-2 antibody, JP2 antibody, jp antibody, 1110002E14Rik antibody, Jp2 antibody, junctophilin 2 antibody, junctophilin-2 antibody, JPH2 antibody, LOC100461095 antibody, LOC610874 antibody, Jph2 antibody
    Background
    Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.Synonyms: JP2
    Gene ID
    57158
    NCBI Accession
    NP_065166
    UniProt
    Q9BR39
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